Prince Harry will join forces with David Cameron in New York to encourage more Americans to visit, study and do business in Britain.
The Prime Minister and the Prince, both in the US on separate official visits, will arrive at a Manhattan media company on a Routemaster bus emblazoned with the words "innovation is great".
The event is part of the Great campaign, a Government initiative which promotes the UK around the world on the back of the success of the Diamond Jubilee and London 2012.
Harry launched the initiative in Brazil last year during an event on Rio de Janeiro's iconic Sugar Loaf mountain with then Culture Secretary Jeremy Hunt.
Mr Cameron held talks with US President Barack Obama at the White House and visited the FBI headquarters in Washington at the start of a three-day visit to America.
Later he will travel to Boston to pay his respects in the city where the recent marathon bombings claimed three lives.
Harry is coming to the end of his seven-day US visit promoting British interests and his own charities. Highlights have included a White House reception with First Lady Michelle Obama, and the royal supporting injured British servicemen and women taking part in the Warrior Games in Colorado Springs.
He will learn how survivors of Superstorm Sandy are rebuilding their lives, properties and businesses in New Jersey.
The ferocious storm that struck the US east coast last October killed more than 120 people and the cost of the clear-up has been estimated at more than £35 billion.
Harry will also attend a baseball event in the Big Apple as he promotes a sports programme involving his Royal Foundation.